Our research applies mathematical, computational, and statistical approaches to answer basic and applied research questions about the ecology and epidemiology of infectious diseases. This work is rooted primarily in mosquito-borne diseases of humans, although our portfolio has expanded in recent years to also include other vector-borne diseases of humans and animals, emerging diseases, and respiratory diseases. Across this range of systems, the goal of our research is to attain a predictive understanding of where and when these diseases occur, what the impact of interventions will be in curtailing their burden, and how the distribution of these diseases and their response to interventions will change over time as a result of changes in their underlying drivers. Through this research, we hope to elevate the rigor of the information on which decision makers act, both in terms of accuracy and quantification of uncertainty.